구강내 악성흑색종에 대한 임상연구
CLINICAL STUDY ON MALIGNANT MELANOMA IN ORAL CAVITY
김욱규, 허진호, 황대석, 김용덕, 신상훈, 김종렬, 정인교,
소속 상세정보
김욱규 ( Kim Uk-Kyu ) - 부산대학교 치과대학 구강악안면외과학교실
허진호 ( He Jin-Ho ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
황대석 ( Hwang Dae-Seok ) - 부산대학교 치과대학 구강악안면외과학교실
김용덕 ( Kim Yong-Deok ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
신상훈 ( Shin Sang-Hun ) - 부산대학교 치과대학 구강안면외과학교실
김종렬 ( Kim Jong-Ryoul ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
정인교 ( Jung In-Kyo ) - 부산대학교 치과대학 구강안면외과학교실
KMID : 0355620080340060611
Abstract
The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, and tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark’s and Breslow’s classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity .
Because data collection from case reports is considered to be the best source of information and should be pooled to analyze key determinants of outcome, We analysed 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital on recent 7 years and reviewed the literatures. Immunohistochemical study on S 100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Three patients who were treated by surgery, chemotherapy are alive, but a patients who couldn’t received benefit care surgically due to poor condition was died of distant metastasis, and two patients who refused to surgery are still alive. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be considered as supporting therapy for malignant melanoma.
키워드
Melanoma;S 100 protein;HMB-45;Clark’s classification
원문 및 링크아웃 정보
등재저널 정보